Thalidomide was developed originally as a mild sedative and worked very well in this application. In the 1950s, the main body of scientific thought was that drugs would not cross the placental barrier, so when thalidomide was discovered to be very effective in dealing with morning sickness, doctors in Europe began to prescribe it for that purpose. The results are well known; many children exposed to this substance were born with horrible deformities.

The anti-animal research claims regarding thalidomide are simple; the research done with animals did not predict the teratogenic (birth defect) effects of thalidomide. A common claim in the animal rights community is that rats, mice, and hamsters did not show any teratogenic effects when thalidomide was in pre-clinical trials. This is a blatant falsehood. Several research projects demonstrated teratogenic effects in rats, mice, hamsters, and primates.

So, the truth is somewhat different. An objective analysis of the thalidomide tragedy reveals just the opposite of what the anti-animal-research people claim. The problem was, in fact, insufficient animal testing. Indeed, thalidomide was never approved in the United States, precisely because the US Food and Drug Administration (FDA) felt that insufficient pre-clinical (animal) testing was done. //

Ironically this same property of thalidomide, namely bonding to developmental DNA, is making it useful in treating cancer patients. //

The question to be posed to the anti-research people at this juncture is simple: "Please explain to us how the lack of application of these highly predictive tests before the release of thalidomide in the European market translates into a failure of animal research, rather than a failure to apply sufficient animal research." //

This is but one example. It's also important to note that animals are currently used not only in research but in the production of medical products; for instance, the production of insulin is generally batch-tested in animals genetically engineered to be diabetic, although in recent years there has been a lot of work done towards a cellular-level test that doesn't involve an animal subject. //

C. S. P. Schofield
6 hours ago
Question for the ‘Animal Rights’ ninnies; are you prepared to take the place of experimental animals? //

frylock234
7 hours ago
Husband works in animal pharma, and they do have to use animals for testing. Basically, the companies seek to reduce their dependence on animal testing whenever possible because it is very expensive among other things, like being a PR issue no matter how humanely you try to conduct the testing. Every national/international entity they conduct business with inspects for test animal treatment among many, many other things although some countries care more about it than others.

Hubs got challenged by an activist once, and he shut her down by asking her when the first live animal test should take place, "In controlled circumstances on a test animal, or the first time your vet injects it into your beloved dog?" //

wildmlm
7 hours ago
Lab testing of animals was inhumane decades ago. All labs receiving federal grants, and most state grants, require institutions to have an Institutional Animal Care Committee (IACUC). All use of animals, including field research, requires an Animal Use Protocol (AUP). The committees are rigorous because violations of requirements can cost the institution millions. The AUP is a pain but understandable. I spent my entire career doing animal field research. The focus on AUPs didn’t ramp up until the late 1970s.

The problem with all the mockery was that Trump's claim was true, as evidenced by an article from CNN of all places, that had been published the day before the debate, and which detailed Harris' answers to a 2019 ACLU questionnaire: https://assets.aclu.org/live/uploads/2024/08/Harris-ACLU-Candidate-Questionnaire.pdf //

To make matters worse, Free Beacon reporter Joe Gabriel Simonson added on Twitter that "In a subsequent exchange, Glasser’s editor said the New Yorker does not 'see a need to issue a correction.'"

said the decision to attempt to correct the candidates was in response to the June 27 CNN debate between Trump and President Biden, whose poor performance led to his exit from the race.

“People were concerned that statements were allowed to just hang and not [be] disputed by the candidate Biden, at the time, or the moderators,” Davis said.

Stephen L. Miller @redsteeze
·
I said the reason for how the moderators behaved in the ABC debate was simply because they were not going to let happen to Kamala Harris, what happened to Joe Biden and here she is admitting it
https://latimes.com/entertainment-arts/business/story/2024-09-11/linsey-davis-abc-news-harris-trump-debate
4:29 PM · Sep 12, 2024 //

FlorenceNightingale
2 hours ago
Davis as much as admitted she had been planning all along to enter the debate on Harris’s side and provide the rebuttal that she didn’t think Harris (like Biden) would be capable of making. Davis must consider Harris as dumb as Biden.

But what should you do to fix the problem when you have deleted an administrator account on Windows 10 by mistake? //

1. Click on the Start button to open Start menu.
2. Press the Shift key and hold it.
3. Choose Restart from the Start menu.
4. Wait for the rebooting until you enter the Windows Recovery Environment.
5. Choose Troubleshoot and Advanced Options to see the window shown below.
6. Select Command Prompt and repeat step 4 ~ 8.
7. Type net user administrator /active: yes and hit Enter.
8. Wait for it to complete.
9. Type net localgroup administrators UserName /add (please replace UserName with your current account name) and hit Enter.
10. Create a new user account with administrator rights.
11. Type net user username * /add

In her closing remarks, Harris noted that she began her career as a prosecutor (Yes, I thought I heard a similar sounding word, too). She rose to California attorney general, U.S. senator and, four years ago, the DEI vice presidential pick of another older man in her life who offered her the allure of power.

“And I’ll tell you, as a prosecutor I never asked a victim or a witness ‘Are you a Republican or a Democrat?’ The only thing I ever asked them, ‘Are you okay?’” Harris said.

And that really is the question, isn’t it? Are you okay? Are you better or worse off after the Biden-Harris governing experiment?

Trump and his running mate, Sen. J.D. Vance, are campaigning on that question — and another.

“So, she just started by saying she’s going to do this, she’s going to do that, she’s going to do all these wonderful things. Why hasn’t she done it?” Trump said in his closing arguments. “She’s been there for 3 1/2 years. They’ve had 3 1/2 years to fix the border. They’ve had 3 1/2 years to create jobs and all the things we talked about. Why hasn’t she done it?”

In a hearing on Wednesday, Rep. Greg Murphy, R-N.C., asked Democrat Michigan Secretary of State Jocelyn Benson if there are dead people on the state’s voter rolls, and she would not answer yes or no.

“Why the hell are deceased people still on your voter rolls?” Murphy asked. “Do you have deceased people on your voter rolls, yes or no?”

“We do everything we can, and just like every other state, to remove — ” Benson said.

“Should a deceased person be on your voter roll?” Murphy insisted.

“No, and that’s why we remove them once we receive information,” Benson replied. //

He brought up a lawsuit by the Public Interest Legal Foundation, which alleged that as of 2021, there were close to 26,000 dead voters on Michigan’s voter rolls. The group claimed Benson did not contest that the dead voters were registered and said she was not taking adequate steps to remove them.

“Why does it take a lawsuit by the Public Interest Legal Foundation to sue you to get those people off the voter rolls?” Murphy asked Benson.

“That lawsuit was dismissed,” Benson replied.

A district judge ruled Benson was performing ongoing list maintenance and tossed out the case, as The Federalist previously reported. But PILF appealed the case to the U.S. 6th Circuit Court of Appeals, saying the court never fully determined Benson was making a “reasonable effort” to remove dead voters from the rolls.

With massive leftist voter registration efforts in play, election integrity advocates warn of many more noncitizens on voter rolls.

For those feeling stuck on older hardware still running windows 10 because of Microsoft’s hardware requirements, be aware that you can upgrade to windows 11 fully legally and without breaking any Microsoft rules.

I did this on a 10 year old I3 machine with 6gb of ram a few months ago. Windows updates automatically continue to run just fine monthly and windows defender updates come through nearly daily just fine also. The only downside I am aware of is that once you upgrade to let’s say windows 23h2, windows will not automatically try to take the machine to windows 24h2 when it comes out. You will need to do that type of upgrade manually using these same instructions. Microsoft is supporting windows 11 sub releases (like win11 23h2) for 2 years after they come out.

My memory is there are 2 requirements to do the upgrade: at least tpm ver 1 and a uefi boot machine (not a master boot machine)

Here is where I got the instructions:
https://dongknows.com/steps-for-windows-11-upgrade-on-unsupported-hardware/

Here are my notes on what I did and where I got good information:
https://lsattle.wordpress.com/2024/09/11/windows-11-upgrading-older-hardware-to-windows-11-and-not-braking-any-rules/
Reply →

Fr00tL00ps
September 12, 2024

Thank you Lynn, Bravo. This is an excellent post and should be pinned to the top so it gets more attention. These resources/links pretty much cover everything you need to know to get Win 11 running on older hardware particularly those on a tight budget who possess a DIY mindset. It is not hard, just follow the instructions.

For context I refuse to replace my Mothers 12 year old Asus N53SV laptop (2nd Gen i5 & 8Gb RAM). It was purchased with Vista and over the years has since had Win 7, Win 10 and currently Win 11 and Office 2007 installed, all with the same product key/s. The only hardware mods it has received is 4Gb extra RAM, an SSD and USB wifi adapter prior to Win 10 fresh install and it has never missed a beat.

Admittedly I am an IT professional and she has very basic needs ie. email, social media and solitaire, but regardless it is still possible. Even paying your local IT technician would be cheaper than purchasing a new machine.

Some other points to consider which aren’t mentioned in your links;

• Win 11 is resource hungry so adding extra RAM would be a benefit.
• Likewise, replace/upgrade OS HDD to an equivalent SSD.
• Disconnect internet cable/wifi connection prior to install. This will force Windows to create a local user account to login rather than signing in with a Microsoft account, which you DO NOT need.
• Once logged in, change two power settings;
  a. create custom power profile and set it to high performance (Microsofts default settings may cause performance issues on older hardware)
  b. disable fast startup. (Caching previous sessions can be a security issue and if you have an SSD there will be negligible gain)
  • Chris Titus Tech’s Windows Utility is an amazing open source tool for home users and it costs nothing. A single Powershell command allows you to; Bulk install/update all your commonly used standard software via Winget. Debloat all your unwanted Microsoft crapware/telemetry/utilities. Tweak many hard to find settings such as Windows updates and repositioning the start button. Watch videos at these links;
    https://christitus.com/windows-tool/
    https://christitus.com/windows-utility-improved/

A lot is said about what a good father is. He's strong, present, tough but fair. All of these are good qualities to have, but one that is ignored in today's society, or denounced once identified, is one you don't often hear about.

Indifference to worldly pressures. //

Brandon Morse @TheBrandonMorse
·
This is fantastic.
At the end of the day, the demand to validate lifestyles of others is going to fall flat on the ears of a father that loves his children, because it's a father's job to stand between his children and danger. Rage and cancel all you want, but a good father… Show more
Nickmercs @NICKMERCS
Stay true to your beliefs
Embedded video
4:24 PM · Sep 10, 2024

This indifference to the world's demands is fueled entirely by his love for his child.

This quality is often the most frustrating thing to the world. Fathers are belittled, disregarded, called "toxic," and hated for what I believe is this often unspoken quality.

Getting to the child is very difficult with a father standing in the way saying "no."

If they can't get to the child, they'll go after the father. They'll try to shame him, pressure him, threaten him, and make him into a pariah. Yet it's the father's duty to stay strong, shrug, and not budge. It's his job to be indifferent to the demands made upon him and his child. His job isn't just to protect the home physically, it's to protect the home's heart as well. //

It can be overwhelming, but sometimes the father must stand up amid all that and say "no, not in my house." He has to reject the pressure on behalf of his family and take on the responsibility of being that wall. You'll often hear this referred to as despotism in the home, but really, it's a father having a calming influence in the lives of his family members, keeping them from sinking into a mire of confusion and harm.

Fathers are built for the fight, but oftentimes the fight isn't physical or forceful. It's calm, quiet, and immovable. It's shrugging at an angry and demanding world, and softly telling it to move on.

Because that's what fathers are built to do. They hold the fort. Their defend the bridge. They protect the home.

This article describes which SRV records should be created for a domain. These SRV records allow clients to automatically detect which host and port should be used for relevant domain services.

setup autoconfig for Outlook

We wrote earlier about the story of Joe Biden going to Shanksville, Pennsylvania, to commemorate 9/11. That's the spot where Flight 93 went down when the passengers heroically tried to take back the plane. Biden visited with first responders and their families at the fire station.

Then came this funny report out of the exchange — that Biden somehow ended up with a Trump hat on his head.

Biden apparently offered one of the local men, a Trump supporter, a presidential hat. He then said he had to have the man's hat, the Trump hat. The frank exchange was hilarious.

https://twitter.com/TPostMillennial/status/1834059129041600854

there's a new debate hoax raging. It centers on Trump's comments about threatening "Abdul," who he cited as a Taliban leader he negotiated with in 2020. The mention sent the fingers of journalists everywhere scurrying on keyboards. Multiple major news outlets, including The Hill and Forbes, wrote mocking headlines and suggested it was "unclear" who Trump was referring to because he's just so darn stupid.

“I got involved. And Abdul is the head of the Taliban. He is still the head of the Taliban,” Trump said. “And I told Abdul, ‘Don’t do it anymore. You do it anymore, you’re going to have problems.’ And he said, ‘Why do you send me a picture of my house?’ I said, ‘You’re going to have to figure that out, Abdul.’ And for 18 months we had nobody killed.”

It’s not clear who Trump was referring to.

Hibatullah Akhundzada is the Taliban’s leader, having been in charge since 2016.

It wasn't unclear, though. I know that because if you read the very same articles I linked above, both go on to explain exactly who Trump was talking about.

Abdul Ghani Baradar is not an obscure figure. He is the co-founder of the Taliban and currently serves as the terrorist government's "prime minister." He was also the lead negotiator and head of policy during the 2020 negotiations. So who is dumber? Trump for citing "Abdul," or the know-nothing journalists who couldn't be bothered to use Google for two minutes? //

RedDog_FLA
an hour ago
This is Golden:

Cable news is filled with over-credentialed mediocrities with the common sense of a lima bean.

That tells everything. //

anon-dion
25 minutes ago
It doesn't matter Journalists can't seem to do their job anymore. Used to be an investigative reporter would run down all the fact and report the results without bias. Now only a handful do. I can think of Catherine Harris, Glen Greenwald, and Matt Tiabi. Everyone else is just trying to score points and get clicks. A sign of a dying media is the need for sensationalism and yellow journalist tactics. //

Arik
27 minutes ago
Wait a minute. Did Kamala mean MANDATORY transgender surgeries for illegals in prison???

Puts a whole new light on it. 😁 //

Rogue Rose
23 minutes ago
Their endless lies are exhausting

KJSpeed Rogue Rose
4 minutes ago
I concur. Kind of like The Boy Who Cried Wolf. They're trying to push us to the point that we challenge everything they say as a lie, then they spin it as "those right-wing MAGA nuts are trying to say that everything we tell you is a lie. Don't believe them!" John and Jane Doe begin to think the liars are telling the truth and everyone that disagrees with them is a liar. Right before the wolf eats them.

Currently, Missouri has one of the strongest laws against abortion — triggered immediately by the Dobbs decision in 2022. If Amendment 3 passes, that law will essentially be gutted. //

Indylawyer
8 hours ago
If I were rich, I'd donate a bunch of money to the groups trying to defeat these ballot initiatives. The idea that there can be a constitutional right to kill an innocent human being is disgustingly repulsive. At stake is not just the lives of many children who deserve protection from abortion, but also the very bedrock of our constitutional order - the right to life recognized by the Declaration of Independence as a "self evident truth." //

Indylawyer anon-g76i
7 hours ago
Or people with "dangerous ideas" or "oppressor" heritage, or low IQs or high risk of disease, who were born into slavery, or whatever defect the government wants to play up at a given time. If rights come from the government and can be allocated based on attributes other than our mere humanity, then all sorts of abuses become possible.

Scott Adams
@scottadamsshow
·
Follow
Megyn Kelly went off on the ABC Debate moderators obvious bias and blames their boss and Kamala’s closest friend for over 30 years, Dana Walden, who also just so happens to run ABC News as co-chairwoman at woke Disney. Kamala’s best friend is the moderators boss!

7:17 AM · Sep 11, 2024 //

etba_ss Orwell was right
20 minutes ago
So why did Trump not know this and publicize it ahead of the debate? Obviously, his staff should have known and told him. They should know everything about Harris and anyone she's ever dealt with on any level.

Pop Crave @PopCrave
·
“Now she wants to do transgender operations on illegal aliens that are in prison."

• Donald Trump on Kamala Harris during the presidential debate

9:50 PM · Sep 10, 2024

https://redstate.com/bonchie/2024/09/09/new-unearthed-aclu-questionnaire-exposes-kamala-harris-dangerously-liberal-beliefs-n2179113

As Kamala Harris pivots to the political center in her campaign for president, a 2019 questionnaire from a leading civil rights organization spotlights her past support for left-wing causes such as taxpayer-funded gender transition surgeries for detained immigrants and federal prisoners. //

EJ @Ejmiller25
·
Even more crazy is that it's 100% undeniably true.
https://t.co/ssEw3wVEw0

JD Vance @JDVance
·
What's even crazier is that Kamala Harris actually did support giving illegal aliens transgender surgeries (paid for by taxpayers).

https://cnn.com/2024/09/09/politics/kfile-harris-pledged-support-in-2019-to-cut-ice-funding-and-provide-transgender-surgery-to-detained-migrants/index.html

Marc Lamont Hill @marclamonthill
"She wants to do transgender operations on illegal aliens who are in prison" is the WILDEST thing I've ever heard in any debate. EVER.
12:40 PM · Sep 11, 2024 //

Harris' positions are so ludicrous that not even her own supporters believe they're true. Perhaps that should cause a bit of introspection. It won't, but it should.

"I think that it's important for journalists to actually get on the ground and uncover this stuff for themselves," he said. "When you have a lot of people saying, “my pets are being abducted” or “geese at the city pond are being abducted and slaughtered right in front of us, this is crazy stuff."

"This town has been ravaged by 20,000 migrants coming in, health care costs are up, housing costs are up," he continued. "Communicable diseases like HIV and TB have skyrocketed in this small Ohio town. This is what Kamala Harris's border policies have done. And I think it's interesting Kaitlan, that the media didn't care about the carnage wrought by these policies until we turned it into a meme about cats and that speaks to the media's failure to care about what's going on in these communities. If we have to meme about it to get the media to care, we're going to keep on doing it because the media could, should care about what's going on."

Collins tried to defend the media, saying they do care which is why the mainstream media is covering these stories, to which Vance noted it was only because of cat memes, and nobody would care about this story if the memes weren't doing damage to the Democrats." //

"Kaitlan, it's a totally fair point, but nobody's calling my office and saying that they saw Bigfoot," said Vance. "What they're calling and saying is we're seeing migrants kidnap our dogs and cats and city officials aren't doing anything about it. Now again, I have a responsibility as a United States Senator. I think the media has a responsibility as an institution that cares about truth, to actually take people seriously when they say their lives have been ruined by this migrant crisis and again, if every single thing that the media says about this story is false, the verifiable facts are that this community has had their lives destroyed by 20,000 migrants coming in and uprooting life."

Trump War Room @TrumpWarRoom
·
PENNSYLVANIA VOTER: President Trump "spoke facts" — while Kamala just "repeated everything that Biden has said in the past." Show more

12:02 AM · Sep 11, 2024 //

anon-g58b
2 hours ago
Muir was strong in his debate with Trump. Harris was a lousy moderator

Why would the debate moderators ask about Democrats inciting a would-be assassin when they can just keep recycling the lie that Trump incited a violent mob? //

Imagine refusing to ask the current vice president whether she regrets any of her hateful anti-Trump rhetoric and the Biden administration’s weaponization of the federal government against Trump that may have inspired an armed nutbag to fire at his head, but asking the former president whether he regrets “anything about what [he] did on” Jan. 6, 2021, even after he explicitly told his supporters to protest “peacefully and patriotically.” (Which David Muir lied about, by the way.) You don’t hate the media enough.

As Trump said at the debate, he “probably took a bullet to the head because of the things that they say about me. They talk about democracy. I’m a threat to democracy. They’re the threat to democracy.” Correct. And the moment Trump brought up that uncomfy assassination topic, Muir pivoted because, you know, the moderators “ha[d] a lot to get to.” //

If the debate did nothing else, it reminded us of their true colors. They aren’t biased. They don’t have a slant. ABC News and CNN and NBC and all the rest of the establishment media don’t “lean left.”

They are propagandists. They live and die for the regime. They are wholly and completely corrupt, a hostile force that exists to accrue power for Democrats.

Here are some of the biggest falsehoods Harris told during her debate with Trump.