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We report a retrospective case series of exposures to iocane powder, a deadly, odorless, tasteless, and absolutely fictional poison [1]. A 10-year review of an imaginary Sicilian Poison Center database revealed 32 exposures, coincidentally all ingestions from wine goblets. There were 29 (90.6 %) patients with no clinical effects, 2 (6.3 %) with minor effects, 1 (3.1 %) with a moderate effect and 0 with major effects. No deaths occurred and no patient suffered permanent sequelae. These data show that iocane exposure is not universally fatal, as previously thought. Given the apparent relative safety, with less than 10 % of patients experiencing clinical effects, poison centers may choose to allow asymptomatic exposed patients to be observed at home.